Assay Detail
Functional
CHEMBL5586012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream trypomastigote form of Trypanosoma brucei Lister 427 assessed as reduction in parasite growth incubated for 72 hrs by alamar blue dye based fluorescence analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 5.00 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.70 |
| CHEMBL5597520 | — | — | 1 | 5.84 |
| CHEMBL5597846 | — | — | 1 | 5.72 |
| CHEMBL5596772 | — | — | 1 | 5.71 |
| CHEMBL5596985 | — | — | 1 | 5.61 |
| CHEMBL5596379 | — | — | 1 | 5.39 |
| CHEMBL5591156 | — | — | 1 | 5.23 |
| CHEMBL5596170 | — | — | 1 | 5.23 |
| CHEMBL5596663 | — | — | 1 | 5.16 |
| CHEMBL5596153 | — | — | 1 | 5.12 |
| CHEMBL5590596 | — | — | 1 | 5.01 |
| CHEMBL5597345 | — | — | 1 | 5.01 |
| CHEMBL5598023 | — | — | 1 | 5.00 |
| CHEMBL5596953 | — | — | 1 | 4.91 |
| CHEMBL5596255 | — | — | 1 | 4.91 |
| CHEMBL5596086 | — | — | 1 | 4.88 |
| CHEMBL5598194 | — | — | 1 | 4.83 |
| CHEMBL5597972 | — | — | 1 | 4.82 |
| CHEMBL305938 | — | — | 1 | 4.78 |
| CHEMBL5590274 | — | — | 1 | 4.69 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 4.64 |
| CHEMBL5596258 | — | — | 1 | 4.58 |
| CHEMBL5596792 | — | — | 1 | 4.55 |
| CHEMBL10962 | — | — | 1 | 4.55 |
| CHEMBL5596950 | — | — | 1 | 4.48 |
| CHEMBL5597935 | — | — | 1 | 4.42 |
| CHEMBL5597849 | — | — | 1 | 4.41 |
| CHEMBL242863 | — | — | 1 | 4.39 |
| CHEMBL5597720 | — | — | 1 | 4.23 |
| CHEMBL5598285 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5597520 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL5597846 | — | EC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL5596772 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5596985 | — | EC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL5596379 | — | EC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL5591156 | — | EC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL5596170 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5596663 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5596153 | — | EC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL5590596 | — | EC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL5597345 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5598023 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5596953 | — | EC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5596255 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL5596086 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5598194 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL5597972 | — | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL305938 | — | EC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5590274 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL1560 | CAPTOPRIL | EC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL5596258 | — | EC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL5596792 | — | EC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL10962 | — | EC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL5596950 | — | EC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL5597935 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5597849 | — | EC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL242863 | — | EC50 | = | 40800.0 | nM | 4.39 |
| CHEMBL5597720 | — | EC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL5598285 | — | EC50 | = | 61500.0 | nM | 4.21 |
| CHEMBL5596359 | — | EC50 | = | 96700.0 | nM | 4.01 |
| CHEMBL5597628 | — | EC50 | = | 106000.0 | nM | - |
| CHEMBL5597271 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL5597141 | — | EC50 | > | 200000.0 | nM | - |