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Assay Detail

CHEMBL5586282

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Immunosuppressive activity in BALB/c mouse T-lymphocytes assessed as inhibition of ConA-induced cell proliferation pretreated with Concanavalin A for 24 hrs followed by compound addition and measured after 48 hrs by CCK-8 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type T-cell
Confidence 1 — Organism
Curated By Autocuration

Target

T-cell (CHEMBL614309)
Type CELL-LINE

Publication

Adpressins A-G: Oligophenalenone Dimers from <i>Talaromyces adpressus</i>.
Zheng M, Li Q, Liao H, Li Y, Zhou C, Zhao X, Chen C, Sun W, Zhang Y, Zhu H.
J Nat Prod (2024) 87 : 1921 -1929
PubMed 39033406 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.17 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5598022 1 5.58
CHEMBL5598191 1 5.03
CHEMBL5597646 1 4.89
CHEMBL5596629 1 -
CHEMBL5596531 1 -
CHEMBL5596782 1 -
CHEMBL5596999 1 -
CHEMBL5597997 1 -
CHEMBL5597339 1 -
CHEMBL5596326 1 -
CHEMBL5598554 1 -
CHEMBL5597029 1 -
CHEMBL5422235 1 -
CHEMBL5598011 1 -
CHEMBL5596093 1 -
CHEMBL4067288 1 -
CHEMBL5596548 1 -
CHEMBL5598477 1 -
CHEMBL5597010 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5598022 IC50 = 2600.0 nM 5.58
CHEMBL5598191 IC50 = 9300.0 nM 5.03
CHEMBL5597646 IC50 = 12800.0 nM 4.89
CHEMBL5596629 IC50 > 40000.0 nM -
CHEMBL5596531 IC50 > 40000.0 nM -
CHEMBL5596782 IC50 > 40000.0 nM -
CHEMBL5596999 IC50 > 40000.0 nM -
CHEMBL5597997 IC50 > 40000.0 nM -
CHEMBL5597339 IC50 > 40000.0 nM -
CHEMBL5596326 IC50 > 40000.0 nM -
CHEMBL5598554 IC50 > 40000.0 nM -
CHEMBL5597029 IC50 > 40000.0 nM -
CHEMBL5422235 IC50 > 40000.0 nM -
CHEMBL5598011 IC50 > 40000.0 nM -
CHEMBL5596093 IC50 > 40000.0 nM -
CHEMBL4067288 IC50 > 40000.0 nM -
CHEMBL5596548 IC50 < 40.0 nM -
CHEMBL5598477 IC50 > 40000.0 nM -
CHEMBL5597010 IC50 > 40000.0 nM -