Assay Detail
Binding
CHEMBL5587988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin) using PI3:PS as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Pyrazolo[1,5-<i>a</i>]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.01 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596530 | — | — | 1 | 9.30 |
| CHEMBL5596755 | — | — | 1 | 9.10 |
| CHEMBL5597639 | — | — | 1 | 8.89 |
| CHEMBL5597286 | — | — | 1 | 8.89 |
| CHEMBL5598309 | — | — | 1 | 8.85 |
| CHEMBL5597371 | — | — | 1 | 8.85 |
| CHEMBL5590633 | — | — | 1 | 8.82 |
| CHEMBL5597786 | — | — | 1 | 8.54 |
| CHEMBL5596364 | — | — | 1 | 8.51 |
| CHEMBL5596579 | — | — | 1 | 8.43 |
| CHEMBL5597293 | — | — | 1 | 8.41 |
| CHEMBL5597159 | — | — | 1 | 8.40 |
| CHEMBL5597218 | — | — | 1 | 8.40 |
| CHEMBL5598560 | — | — | 1 | 8.35 |
| CHEMBL5598183 | — | — | 1 | 8.28 |
| CHEMBL5598454 | — | — | 1 | 8.26 |
| CHEMBL5590113 | — | — | 1 | 8.20 |
| CHEMBL5596957 | — | — | 1 | 8.19 |
| CHEMBL5597322 | — | — | 1 | 8.14 |
| CHEMBL5596476 | — | — | 1 | 8.12 |
| CHEMBL5596611 | — | — | 1 | 8.07 |
| CHEMBL5596470 | — | — | 1 | 8.07 |
| CHEMBL5596114 | — | — | 1 | 8.00 |
| CHEMBL5597160 | — | — | 1 | 7.87 |
| CHEMBL5598104 | — | — | 1 | 7.71 |
| CHEMBL5597903 | — | — | 1 | 7.70 |
| CHEMBL5591233 | — | — | 1 | 7.68 |
| CHEMBL5596735 | — | — | 1 | 7.58 |
| CHEMBL5596396 | — | — | 1 | 7.53 |
| CHEMBL5597953 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596530 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5596755 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5597286 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5597639 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5598309 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5597371 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5590633 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5597786 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5596364 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5596579 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5597293 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5597159 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5597218 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5598560 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5598183 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5598454 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5590113 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5596957 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5597322 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5596476 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5596470 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5596611 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5596114 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL5597160 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL5598104 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL5597903 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL5591233 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5596735 | — | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL5596396 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL5597953 | — | IC50 | = | 37.8 | nM | 7.42 |
| CHEMBL5597610 | — | IC50 | = | 38.6 | nM | 7.41 |
| CHEMBL5590382 | — | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL5596701 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL5596644 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL5597669 | — | IC50 | = | 146.9 | nM | 6.83 |
| CHEMBL5591103 | — | IC50 | = | 396.9 | nM | 6.40 |
| CHEMBL5597788 | — | IC50 | = | 929.0 | nM | 6.03 |
| CHEMBL5596348 | — | IC50 | > | 10000.0 | nM | - |