Compound Detail
CHEMBL5596755
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Basic Information
| ChEMBL ID | CHEMBL5596755 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CRXLXOVZGMTILX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
400.4
MW (Da)
2.36
ALogP
8
HBA
2
HBD
111.9
PSA (Ų)
0.56
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 7.87 | 7.87 | 13.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 0.8 | nM | 9.1 | Inhibition of PI3Kgamma (unknown origin) using PI3:PS as substrate incubated for... | 39163191 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 13.6 | nM | 7.87 | Inhibition of PI3K alpha (unknown origin) using PI3:PS as substrate incubated fo... | 39163191 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39163191 | 10.1021/acs.jmedchem.4c00817 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 39163191 | 10.1021/acs.jmedchem.4c00817 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine