Assay Detail
Functional
CHEMBL5588045
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Antiproliferative activity against human ZR-75-1 cells incubated for 48 to 96 hrs by CCK-8 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ZR-75-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of <i>CCNE1</i>-Amplified Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.14 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5598294 | — | — | 1 | 5.38 |
| CHEMBL5597451 | — | — | 1 | 5.36 |
| CHEMBL5596280 | — | — | 1 | 5.32 |
| CHEMBL5598020 | — | — | 1 | 5.30 |
| CHEMBL5596250 | — | — | 1 | 5.25 |
| CHEMBL5598459 | — | — | 1 | 5.15 |
| CHEMBL5596480 | — | — | 1 | 5.07 |
| CHEMBL5597660 | — | — | 1 | 5.07 |
| CHEMBL5597456 | — | — | 1 | 4.94 |
| CHEMBL5199076 | LUNRESERTIB | 2.0 | 1 | 4.85 |
| CHEMBL5596068 | — | — | 1 | 4.81 |
| CHEMBL5597465 | — | — | 1 | - |
| CHEMBL5596497 | — | — | 1 | - |
| CHEMBL5598536 | — | — | 1 | - |
| CHEMBL5597843 | — | — | 1 | - |
| CHEMBL5598426 | — | — | 1 | - |
| CHEMBL5596854 | — | — | 1 | - |
| CHEMBL5597966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5598294 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL5597451 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5596280 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL5598020 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL5596250 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5598459 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL5596480 | — | IC50 | = | 8490.0 | nM | 5.07 |
| CHEMBL5597660 | — | IC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL5597456 | — | IC50 | = | 11580.0 | nM | 4.94 |
| CHEMBL5199076 | LUNRESERTIB | IC50 | = | 14020.0 | nM | 4.85 |
| CHEMBL5596068 | — | IC50 | = | 15420.0 | nM | 4.81 |
| CHEMBL5597465 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5596497 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5598536 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5597843 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5598426 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5596854 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5597966 | — | IC50 | > | 20000.0 | nM | - |