Assay Detail
ADMET
CHEMBL5610163
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Inhibition of recombinant CYP2D6 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.31 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5613131 | — | — | 1 | 6.40 |
| CHEMBL5612929 | — | — | 1 | 6.22 |
| CHEMBL5614007 | — | — | 1 | 5.17 |
| CHEMBL5614058 | — | — | 1 | 5.17 |
| CHEMBL5612296 | — | — | 1 | 5.11 |
| CHEMBL5612188 | — | — | 1 | 5.06 |
| CHEMBL5613587 | — | — | 1 | 4.82 |
| CHEMBL214957 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5613131 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5612929 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5614007 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5614058 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5612296 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5612188 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5613587 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL214957 | — | IC50 | = | 30000.0 | nM | 4.52 |