Assay Detail
Binding
CHEMBL5611212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by DNTB reagent based Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with <i>In Vitro</i> and <i>In Vivo</i> Activity in Neurodegenerative Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.50 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.52 |
| CHEMBL5612956 | — | — | 1 | 5.93 |
| CHEMBL5613964 | — | — | 1 | 5.05 |
| CHEMBL268229 | — | — | 1 | - |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5612956 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5613964 | — | IC50 | = | 8806.0 | nM | 5.05 |
| CHEMBL268229 | — | IC50 | - | — | - | |
| CHEMBL396778 | SAFINAMIDE | IC50 | - | — | - | |
| CHEMBL887 | RASAGILINE | IC50 | - | — | - |