Assay Detail
Functional
CHEMBL5614673
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Antiproliferative activity against human A2780 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxamic acid hybrids: Histone deacetylase inhibitors with anticancer therapeutic potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.83 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.42 |
| CHEMBL5619224 | — | — | 1 | 5.67 |
| CHEMBL5619894 | — | — | 1 | 5.64 |
| CHEMBL5618862 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5619224 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL5619894 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5618862 | — | IC50 | = | 2620.0 | nM | 5.58 |