Assay Detail
Binding
CHEMBL5614961
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Inhibition of human SERT expressed in HEK293 cells incubated for 30 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.16 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.17 |
| CHEMBL5618995 | — | — | 1 | 8.70 |
| CHEMBL5620090 | — | — | 1 | 8.52 |
| CHEMBL5618877 | — | — | 1 | 7.92 |
| CHEMBL5619646 | — | — | 1 | 7.47 |
| CHEMBL5619208 | — | — | 1 | 7.40 |
| CHEMBL5619328 | — | — | 1 | 7.32 |
| CHEMBL5619931 | — | — | 1 | 7.19 |
| CHEMBL5620043 | — | — | 1 | 7.14 |
| CHEMBL5618922 | — | — | 1 | 7.10 |
| CHEMBL5620117 | — | — | 1 | 6.97 |
| CHEMBL5620061 | — | — | 1 | 6.86 |
| CHEMBL5618136 | — | — | 1 | 6.84 |
| CHEMBL5619007 | — | — | 1 | 6.82 |
| CHEMBL5618693 | — | — | 1 | 6.45 |
| CHEMBL5619076 | — | — | 1 | 6.33 |
| CHEMBL5618780 | — | — | 1 | 5.58 |
| CHEMBL5618601 | — | — | 1 | 5.17 |
| CHEMBL5620209 | — | — | 1 | - |
| CHEMBL5619978 | — | — | 1 | - |
| CHEMBL5619395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL5618995 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5620090 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5618877 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5619646 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5619208 | — | IC50 | = | 39.7 | nM | 7.40 |
| CHEMBL5619328 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5619931 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5620043 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5618922 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5620117 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5620061 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL5618136 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL5619007 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5618693 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL5619076 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL5618780 | — | IC50 | = | 2642.0 | nM | 5.58 |
| CHEMBL5618601 | — | IC50 | = | 6757.0 | nM | 5.17 |
| CHEMBL5620209 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5619978 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5619395 | — | IC50 | > | 30000.0 | nM | - |