Assay Detail
Binding
CHEMBL5616069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK1 (unknown origin) incubated for 10 mins in presence of ATP by mobility shift assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Nitric Oxide-Donating Netarsudil Derivatives as a Synergistic Therapy for Glaucoma with Reduced Ocular Irritation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.05 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5619410 | — | — | 1 | 8.90 |
| CHEMBL5618424 | — | — | 1 | 8.83 |
| CHEMBL5618715 | — | — | 1 | 8.60 |
| CHEMBL5619145 | — | — | 1 | 8.31 |
| CHEMBL4594250 | NETARSUDIL | 4.0 | 1 | 7.88 |
| CHEMBL3426621 | RIPASUDIL | 3.0 | 1 | 7.76 |
| CHEMBL5619199 | — | — | 1 | 7.65 |
| CHEMBL5619370 | — | — | 1 | 7.54 |
| CHEMBL5619614 | — | — | 1 | 7.54 |
| CHEMBL5619023 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5619410 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL5618424 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL5618715 | — | IC50 | = | 2.54 | nM | 8.60 |
| CHEMBL5619145 | — | IC50 | = | 4.94 | nM | 8.31 |
| CHEMBL4594250 | NETARSUDIL | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL3426621 | RIPASUDIL | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL5619199 | — | IC50 | = | 22.47 | nM | 7.65 |
| CHEMBL5619370 | — | IC50 | = | 28.98 | nM | 7.54 |
| CHEMBL5619614 | — | IC50 | = | 28.61 | nM | 7.54 |
| CHEMBL5619023 | — | IC50 | = | 35.41 | nM | 7.45 |