Assay Detail
Binding
CHEMBL5624382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at VHL/HiBit tagged AR in human LNCaP cells cells assessed as degradation of AR incubated for 18 hrs by Nano-Glo HiBiT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor/Androgen receptor (CHEMBL4523730) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.48 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555109 | — | — | 1 | 6.67 |
| CHEMBL5560053 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555109 | — | EC50 | = | 212.0 | nM | 6.67 |
| CHEMBL5560053 | — | EC50 | = | 527.0 | nM | 6.28 |