Compound Detail
CHEMBL5555109
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1cc([C@H](C(=O)N2C[C@H](S(=O)(=O)F)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1
Basic Information
| ChEMBL ID | CHEMBL5555109 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YVXTYEKDOUWSSR-AYXOQTJASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1078.7
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/Androgen receptor CHEMBL4523730 | EC50 | 6.67 | 6.67 | 212.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/Androgen receptor | EC50 | = | 212.0 | nM | 6.67 | PROTAC activity at VHL/HiBit tagged AR in human LNCaP cells cells assessed as de... | 38478885 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38478885 | 10.1021/acs.jmedchem.3c02123 | von Hippel-Lindau disease tumor suppressor/Androgen receptor | 4 |
| 38199162 | 10.1016/j.ejmech.2023.116041 | von Hippel-Lindau disease tumor suppressor/Androgen receptor | 2 |
| 38478885 | 10.1021/acs.jmedchem.3c02123 | LNCaP | 1 |
Data from ChEMBL 36 via Core Engine