Assay Detail
Functional
CHEMBL5627598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 IIIB infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.68 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.60 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.49 |
| CHEMBL5632459 | — | — | 1 | 8.41 |
| CHEMBL5633326 | — | — | 1 | 8.25 |
| CHEMBL5633910 | — | — | 1 | 8.23 |
| CHEMBL5633591 | — | — | 1 | 8.23 |
| CHEMBL5633694 | — | — | 1 | 8.22 |
| CHEMBL5632723 | — | — | 1 | 8.13 |
| CHEMBL5631702 | — | — | 1 | 8.11 |
| CHEMBL5633430 | — | — | 1 | 8.08 |
| CHEMBL5631453 | — | — | 1 | 7.98 |
| CHEMBL5631703 | — | — | 1 | 7.95 |
| CHEMBL5631612 | — | — | 1 | 7.85 |
| CHEMBL5633387 | — | — | 1 | 7.84 |
| CHEMBL5631263 | — | — | 1 | 7.66 |
| CHEMBL5632834 | — | — | 1 | 7.60 |
| CHEMBL5633937 | — | — | 1 | 7.57 |
| CHEMBL5631339 | — | — | 1 | 7.54 |
| CHEMBL104245 | — | — | 1 | 7.52 |
| CHEMBL5631439 | — | — | 1 | 7.49 |
| CHEMBL5633629 | — | — | 1 | 7.39 |
| CHEMBL5632955 | — | — | 1 | 7.35 |
| CHEMBL5632948 | — | — | 1 | 7.16 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.13 |
| CHEMBL5631315 | — | — | 1 | 6.94 |
| CHEMBL5632621 | — | — | 1 | 6.71 |
| CHEMBL5633311 | — | — | 1 | 6.70 |
| CHEMBL5633692 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.53 | nM | 8.60 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 3.22 | nM | 8.49 |
| CHEMBL5632459 | — | EC50 | = | 3.87 | nM | 8.41 |
| CHEMBL5633326 | — | EC50 | = | 5.62 | nM | 8.25 |
| CHEMBL5633910 | — | EC50 | = | 5.83 | nM | 8.23 |
| CHEMBL5633591 | — | EC50 | = | 5.82 | nM | 8.23 |
| CHEMBL5633694 | — | EC50 | = | 6.02 | nM | 8.22 |
| CHEMBL5632723 | — | EC50 | = | 7.47 | nM | 8.13 |
| CHEMBL5631702 | — | EC50 | = | 7.82 | nM | 8.11 |
| CHEMBL5633430 | — | EC50 | = | 8.32 | nM | 8.08 |
| CHEMBL5631453 | — | EC50 | = | 10.4 | nM | 7.98 |
| CHEMBL5631703 | — | EC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5631612 | — | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL5633387 | — | EC50 | = | 14.5 | nM | 7.84 |
| CHEMBL5631263 | — | EC50 | = | 21.8 | nM | 7.66 |
| CHEMBL5632834 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5633937 | — | EC50 | = | 26.9 | nM | 7.57 |
| CHEMBL5631339 | — | EC50 | = | 28.7 | nM | 7.54 |
| CHEMBL104245 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5631439 | — | EC50 | = | 32.7 | nM | 7.49 |
| CHEMBL5633629 | — | EC50 | = | 40.7 | nM | 7.39 |
| CHEMBL5632955 | — | EC50 | = | 44.9 | nM | 7.35 |
| CHEMBL5632948 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 73.7 | nM | 7.13 |
| CHEMBL5631315 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5632621 | — | EC50 | = | 197.0 | nM | 6.71 |
| CHEMBL5633311 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5633692 | — | EC50 | = | 1461.0 | nM | 5.83 |