Compound Detail
CHEMBL5633629
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1cc(C#N)cc(C)c1Oc1ccc(C#N)c(Nc2ccc(CN3CCN(S(C)(=O)=O)CC3)cc2)n1
Basic Information
| ChEMBL ID | CHEMBL5633629 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PFNMFNLWOVHJAQ-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
516.6
MW (Da)
4.05
ALogP
8
HBA
1
HBD
122.3
PSA (Ų)
0.50
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.39
IC50 1 meas. best 6.56
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 7.39 | 7.39 | 40.7 | 1 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 6.56 | 6.56 | 277.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus 1 | EC50 | = | 40.7 | nM | 7.39 | Antiviral activity against wild type HIV-1 IIIB infected in human MT4 cells asse... | 37536208 |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 277.0 | nM | 6.56 | Inhibition of wild type HIV-1 reverse transcriptase assessed as inhibition of bi... | 37536208 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37536208 | 10.1016/j.ejmech.2023.115686 | Human immunodeficiency virus 2 | 1 |
| 37536208 | 10.1016/j.ejmech.2023.115686 | Human immunodeficiency virus 1 | 1 |
| 37536208 | 10.1016/j.ejmech.2023.115686 | MT4 | 1 |
| 37536208 | 10.1016/j.ejmech.2023.115686 | ADMET | 1 |
| 37536208 | 10.1016/j.ejmech.2023.115686 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine