Assay Detail
Binding
CHEMBL5628215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT<sub>6</sub>R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.53 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.60 |
| CHEMBL4873127 | — | — | 1 | 6.30 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.56 |
| CHEMBL5632197 | — | — | 1 | 5.01 |
| CHEMBL5632758 | — | — | 1 | 5.00 |
| CHEMBL5632000 | — | — | 1 | 5.00 |
| CHEMBL5633074 | — | — | 1 | 4.92 |
| CHEMBL5631952 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4873127 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL5632197 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5632758 | — | IC50 | = | 9950.0 | nM | 5.00 |
| CHEMBL5632000 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5633074 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL5631952 | — | IC50 | = | 15000.0 | nM | 4.82 |