Assay Detail
Binding
CHEMBL5628520
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Inhibition of HSP90beta (unknown origin) incubated for 24 hrs by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of X10g as a selective PROTAC degrader of Hsp90α protein for treating breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.58 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215467 | — | — | 1 | 8.40 |
| CHEMBL4474770 | — | — | 1 | 6.75 |
| CHEMBL5633917 | — | — | 1 | 5.80 |
| CHEMBL1254575 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215467 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4474770 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5633917 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1254575 | — | IC50 | = | 4470.0 | nM | 5.35 |