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Assay Detail

CHEMBL5634576

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Binding
Inhibition of mushroom Tyrosinase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Mushroom tyrosinase (CHEMBL6066154)
Type PROTEIN FAMILY
Organism Agaricus bisporus

Publication

Catechol-mimicking transition-state analogues as non-oxidizable inhibitors of tyrosinases.
Beaumet M, Lazinski LM, Maresca M, Haudecoeur R.
Eur J Med Chem (2023) 259 : 115672 -115672
PubMed 37487307 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.26 7.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1269426 1 7.06
CHEMBL2012553 1 5.85
CHEMBL2031845 1 5.70
CHEMBL5639391 1 5.52
CHEMBL5280416 1 5.44
CHEMBL4572517 1 5.40
CHEMBL5639123 1 5.28
CHEMBL1928639 1 5.27
CHEMBL5646386 1 5.16
CHEMBL5639377 1 5.11
CHEMBL5273014 1 5.10
CHEMBL3810334 1 5.05
CHEMBL1818888 1 5.00
CHEMBL5646975 1 4.99
CHEMBL5271322 1 4.92
CHEMBL5641663 1 4.80
CHEMBL70927 DEFERIPRONE 4.0 1 4.52
CHEMBL481194 1 4.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1269426 IC50 = 87.0 nM 7.06
CHEMBL2012553 IC50 = 1400.0 nM 5.85
CHEMBL2031845 IC50 = 2000.0 nM 5.70
CHEMBL5639391 IC50 = 3000.0 nM 5.52
CHEMBL5280416 IC50 = 3600.0 nM 5.44
CHEMBL4572517 IC50 = 4000.0 nM 5.40
CHEMBL5639123 IC50 = 5300.0 nM 5.28
CHEMBL1928639 IC50 = 5400.0 nM 5.27
CHEMBL5646386 IC50 = 7000.0 nM 5.16
CHEMBL5639377 IC50 = 7800.0 nM 5.11
CHEMBL5273014 IC50 = 8000.0 nM 5.10
CHEMBL3810334 IC50 = 9000.0 nM 5.05
CHEMBL1818888 IC50 = 10000.0 nM 5.00
CHEMBL5646975 IC50 = 10300.0 nM 4.99
CHEMBL5271322 IC50 = 12000.0 nM 4.92
CHEMBL5641663 IC50 = 16000.0 nM 4.80
CHEMBL70927 DEFERIPRONE IC50 = 30000.0 nM 4.52
CHEMBL481194 IC50 = 36000.0 nM 4.44