Compound Detail
CHEMBL5273014
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5273014 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DXPWSSBDURBMJV-SFQUDFHCSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
294.4
MW (Da)
3.28
ALogP
5
HBA
1
HBD
63.8
PSA (Ų)
0.41
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosinase CHEMBL3318 | IC50 | 5.8 | 5.45 | 1600.0 | 2 |
| Mushroom tyrosinase CHEMBL6066154 | IC50 | 5.1 | 5.1 | 8000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosinase | IC50 | = | 1600.0 | nM | 5.8 | Inhibition of mushroom tyrosinase monophenolase activity | 34023737 |
| Tyrosinase | IC50 | = | 7990.0 | nM | 5.1 | Inhibition of mushroom tyrosinase diphenolase activity | 34023737 |
| Mushroom tyrosinase | IC50 | = | 8000.0 | nM | 5.1 | Inhibition of mushroom Tyrosinase | 37487307 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34023737 | 10.1016/j.ejmech.2021.113546 | Tyrosinase | 2 |
| 37487307 | 10.1016/j.ejmech.2023.115672 | Mushroom tyrosinase | 1 |
Data from ChEMBL 36 via Core Engine