Assay Detail
Functional
CHEMBL5649056
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Antiproliferative activity against human T47D cells assessed as reduction of cell growth measured after 5 days by CellTiter-Glo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.83 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795065 | Borussertib | — | 1 | 7.32 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.39 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 6.32 |
| CHEMBL5267341 | — | — | 1 | 5.94 |
| CHEMBL5282715 | — | — | 1 | 5.84 |
| CHEMBL5649162 | — | — | 1 | 5.53 |
| CHEMBL5649156 | — | — | 1 | 5.18 |
| CHEMBL5649154 | — | — | 1 | 5.01 |
| CHEMBL5649160 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795065 | Borussertib | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1079175 | MK-2206 | EC50 | = | 411.0 | nM | 6.39 |
| CHEMBL2325741 | CAPIVASERTIB | EC50 | = | 475.0 | nM | 6.32 |
| CHEMBL5267341 | — | EC50 | = | 1146.0 | nM | 5.94 |
| CHEMBL5282715 | — | EC50 | = | 1448.0 | nM | 5.84 |
| CHEMBL5649162 | — | EC50 | = | 2933.0 | nM | 5.53 |
| CHEMBL5649156 | — | EC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL5649154 | — | EC50 | = | 9763.0 | nM | 5.01 |
| CHEMBL5649160 | — | EC50 | = | 11735.0 | nM | 4.93 |