Assay Detail
Functional
CHEMBL5653733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against LPS-induced human THP-1 cells assessed as reduction in IL-8 cytokine level preincubated for 1 hr followed by LPS-stimulation and measured after 6 hrs by enzyme immunoassay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249697 | BMS-345541 | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249697 | BMS-345541 | IC50 | = | 1000.0 | nM | 6.00 |