Assay Detail
Binding
CHEMBL5654101
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Inhibition of p110 beta (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.98 | 9.00 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 9.00 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 7.57 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 7.48 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.36 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.12 |
| CHEMBL3349370 | — | — | 1 | 6.95 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.78 |
| CHEMBL3360203 | PILARALISIB | 2.0 | 1 | 6.42 |
| CHEMBL1213082 | — | — | 1 | 4.12 |
| CHEMBL411907 | SONOLISIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3349370 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3360203 | PILARALISIB | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL1213082 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL411907 | SONOLISIB | IC50 | > | 300.0 | nM | - |