Assay Detail
Functional
CHEMBL5665191
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Antagonist activity against GPR65 (unknown origin) transfected in human HEK293T cells incubated for 15 mins by luminescence counter analysis
5
Total Activities
5
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| EC50 | 2 | 5.71 | 6.30 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0009386 |
| EFO_TERM | EFO_TERM | - | — | central nervous system disease |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1492152 | — | — | 1 | 6.30 |
| CHEMBL4524214 | — | — | 1 | 5.11 |
| CHEMBL5665429 | — | — | 1 | - |
| CHEMBL5665423 | — | — | 1 | - |
| CHEMBL5665395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1492152 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4524214 | — | EC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL5665429 | — | Activity | - | — | - | |
| CHEMBL5665423 | — | Activity | - | — | - | |
| CHEMBL5665395 | — | Activity | - | — | - |