Assay Detail

CHEMBL5680688

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell proliferation incubated for 3 days by CellTiter-Glo Luminescent Cell Viability Assay

ChEMBL ↗

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Target

ZR-75-1 (CHEMBL614393) ↗

Open DB target context

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ZR-75-1 (CHEMBL614393) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target ZR-75-1

CHEMBL614393

Anchored from Assay target.

Protein identity ZR-75-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	ZR-75-1
Confidence	1 — Organism
Curated By	Autocuration

Target

ZR-75-1 (CHEMBL614393) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.

Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T.
Proc Natl Acad Sci U S A (2010) 107 : 9446 -9451
PubMed 20439741 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.31	9.31

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3128043	PF-03758309	1.0	1	9.31

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3128043	PF-03758309	IC50	=	0.49	nM	9.31