Assay Detail
Functional
CHEMBL5712032
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Antiproliferative activity against human T47D cells assessed as reduction in cell viability incubated for 5 days by celltiter-glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.63 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5712048 | — | — | 1 | 7.96 |
| CHEMBL5712063 | — | — | 1 | 7.60 |
| CHEMBL5712045 | — | — | 1 | 7.39 |
| CHEMBL4795065 | Borussertib | — | 1 | 7.32 |
| CHEMBL5712042 | — | — | 1 | 7.02 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.90 |
| CHEMBL5712046 | — | — | 1 | 6.75 |
| CHEMBL5712066 | — | — | 1 | 6.74 |
| CHEMBL5712049 | — | — | 1 | 6.47 |
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 6.35 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 6.32 |
| CHEMBL5712044 | — | — | 1 | 6.26 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.23 |
| CHEMBL5712058 | — | — | 1 | 6.08 |
| CHEMBL5712055 | — | — | 1 | 5.87 |
| CHEMBL5712059 | — | — | 1 | 5.72 |
| CHEMBL5712061 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5712048 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5712063 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5712045 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4795065 | Borussertib | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5712042 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5712046 | — | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL5712066 | — | EC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5712049 | — | EC50 | = | 336.0 | nM | 6.47 |
| CHEMBL2177390 | IPATASERTIB | EC50 | = | 443.0 | nM | 6.35 |
| CHEMBL2325741 | CAPIVASERTIB | EC50 | = | 475.0 | nM | 6.32 |
| CHEMBL5712044 | — | EC50 | = | 546.0 | nM | 6.26 |
| CHEMBL1079175 | MK-2206 | EC50 | = | 583.0 | nM | 6.23 |
| CHEMBL5712058 | — | EC50 | = | 832.0 | nM | 6.08 |
| CHEMBL5712055 | — | EC50 | = | 1359.0 | nM | 5.87 |
| CHEMBL5712059 | — | EC50 | = | 1897.0 | nM | 5.72 |
| CHEMBL5712061 | — | EC50 | = | 2114.0 | nM | 5.67 |