Assay Detail
Functional
CHEMBL5712033
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Antiproliferative activity against human ZR-75-1 cells assessed as reduction in cell viability incubated for 5 days by celltiter-glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ZR-75-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.38 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5712048 | — | — | 1 | 8.70 |
| CHEMBL5712063 | — | — | 1 | 8.70 |
| CHEMBL4795065 | Borussertib | — | 1 | 8.30 |
| CHEMBL5712046 | — | — | 1 | 8.00 |
| CHEMBL5712042 | — | — | 1 | 7.96 |
| CHEMBL5712045 | — | — | 1 | 7.66 |
| CHEMBL5712066 | — | — | 1 | 7.48 |
| CHEMBL5712049 | — | — | 1 | 7.41 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 7.20 |
| CHEMBL5712044 | — | — | 1 | 7.14 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL5712058 | — | — | 1 | 6.94 |
| CHEMBL5712055 | — | — | 1 | 6.82 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 6.72 |
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 6.66 |
| CHEMBL5712059 | — | — | 1 | 6.42 |
| CHEMBL5712061 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5712048 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5712063 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4795065 | Borussertib | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5712046 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5712042 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5712045 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5712066 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5712049 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1079175 | MK-2206 | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5712044 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5712058 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL5712055 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2325741 | CAPIVASERTIB | EC50 | = | 191.0 | nM | 6.72 |
| CHEMBL2177390 | IPATASERTIB | EC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5712059 | — | EC50 | = | 384.0 | nM | 6.42 |
| CHEMBL5712061 | — | EC50 | = | 427.0 | nM | 6.37 |