Assay Detail
ADMET
CHEMBL5716556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 in human liver microsomes assessed as reduction in midazolam metabolism
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.92 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5274003 | — | — | 1 | 5.64 |
| CHEMBL5723015 | — | — | 1 | 5.57 |
| CHEMBL5723002 | — | — | 1 | 4.52 |
| CHEMBL5428272 | — | — | 1 | 4.47 |
| CHEMBL1971943 | BAY-549 | — | 1 | 4.39 |
| CHEMBL5722974 | — | — | 1 | - |
| CHEMBL5722966 | — | — | 1 | - |
| CHEMBL5722984 | — | — | 1 | - |
| CHEMBL5270382 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5274003 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5723015 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5723002 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5428272 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1971943 | BAY-549 | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL5722974 | — | IC50 | - | — | - | |
| CHEMBL5722966 | — | IC50 | - | — | - | |
| CHEMBL5722984 | — | IC50 | - | — | - | |
| CHEMBL5270382 | — | IC50 | - | — | - |