Assay Detail
Binding
CHEMBL5737355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition for Cytochrome P450 Isoenzymes: To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymes
30
Total Activities
10
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.78 | 5.34 |
| kon | 10 | - | - |
| k_off | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443262 | OLICERIDINE | 4.0 | 3 | 5.34 |
| CHEMBL5757634 | — | — | 3 | 5.28 |
| CHEMBL5083403 | — | — | 3 | 4.90 |
| CHEMBL5828732 | — | — | 3 | 4.76 |
| CHEMBL5865602 | — | — | 3 | 4.75 |
| CHEMBL5934477 | — | — | 3 | 4.71 |
| CHEMBL6055562 | — | — | 3 | 4.63 |
| CHEMBL5874951 | — | — | 3 | 4.61 |
| CHEMBL5080554 | — | — | 3 | 4.45 |
| CHEMBL5075300 | — | — | 3 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443262 | OLICERIDINE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5757634 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5083403 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL5828732 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL5865602 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL5934477 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL6055562 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL5874951 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL5080554 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL5075300 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL6055562 | — | k_off | = | - | s-1 | - |
| CHEMBL6055562 | — | kon | = | - | — | - |
| CHEMBL5828732 | — | k_off | = | - | s-1 | - |
| CHEMBL5828732 | — | kon | = | - | — | - |
| CHEMBL5075300 | — | k_off | = | - | s-1 | - |
| CHEMBL5075300 | — | kon | = | - | — | - |
| CHEMBL5080554 | — | k_off | = | - | s-1 | - |
| CHEMBL5080554 | — | kon | = | - | — | - |
| CHEMBL2443262 | OLICERIDINE | k_off | = | - | s-1 | - |
| CHEMBL2443262 | OLICERIDINE | kon | = | - | — | - |
| CHEMBL5083403 | — | kon | = | - | — | - |
| CHEMBL5083403 | — | k_off | = | - | s-1 | - |
| CHEMBL5874951 | — | kon | = | - | — | - |
| CHEMBL5757634 | — | kon | = | - | — | - |
| CHEMBL5874951 | — | k_off | = | - | s-1 | - |
| CHEMBL5934477 | — | kon | = | - | — | - |
| CHEMBL5934477 | — | k_off | = | - | s-1 | - |
| CHEMBL5757634 | — | k_off | = | - | s-1 | - |
| CHEMBL5865602 | — | kon | = | - | — | - |
| CHEMBL5865602 | — | k_off | = | - | s-1 | - |