Assay Detail
Binding
CHEMBL5737893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The biochemical evaluation of the exemplary compounds : This assay is not specified.
18
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-2/gamma-2 (CHEMBL2095172) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
19-NOR neuroactive steroids and methods of use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.92 | 6.12 |
| kon | 6 | - | - |
| k_off | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5766931 | — | — | 3 | 6.12 |
| CHEMBL5750569 | — | — | 3 | 6.12 |
| CHEMBL3427547 | — | — | 3 | 5.82 |
| CHEMBL3427548 | — | — | 3 | 5.82 |
| CHEMBL3427538 | — | — | 3 | 5.82 |
| CHEMBL3427540 | — | — | 3 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5750569 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5766931 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3427540 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3427547 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3427538 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3427548 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5766931 | — | kon | = | - | — | - |
| CHEMBL5766931 | — | k_off | = | - | s-1 | - |
| CHEMBL5750569 | — | kon | = | - | — | - |
| CHEMBL5750569 | — | k_off | = | - | s-1 | - |
| CHEMBL3427547 | — | kon | = | - | — | - |
| CHEMBL3427547 | — | k_off | = | - | s-1 | - |
| CHEMBL3427548 | — | kon | = | - | — | - |
| CHEMBL3427548 | — | k_off | = | - | s-1 | - |
| CHEMBL3427538 | — | kon | = | - | — | - |
| CHEMBL3427538 | — | k_off | = | - | s-1 | - |
| CHEMBL3427540 | — | kon | = | - | — | - |
| CHEMBL3427540 | — | k_off | = | - | s-1 | - |