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Assay Detail

CHEMBL615252

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against 12-lipoxygenase in rat platelet rich plasma
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Plasma
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Arachidonate 12-lipoxygenase (CHEMBL2741)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase.
Cho H, Ueda M, Tamaoka M, Hamaguchi M, Aisaka K, Kiso Y, Inoue T, Ogino R, Tatsuoka T, Ishihara T.
J Med Chem (1991) 34 : 1503 -1505
PubMed 2016727 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.16 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37081 1 7.89
CHEMBL8260 BAICALEIN 2.0 1 7.82
CHEMBL38168 1 7.48
CHEMBL37154 1 7.29
CHEMBL35934 1 7.28
CHEMBL37141 1 7.20
CHEMBL37180 1 7.19
CHEMBL36376 1 6.75
CHEMBL417327 1 6.33
CHEMBL36649 1 6.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37081 IC50 = 13.0 nM 7.89
CHEMBL8260 BAICALEIN IC50 = 15.0 nM 7.82
CHEMBL38168 IC50 = 33.0 nM 7.48
CHEMBL37154 IC50 = 51.0 nM 7.29
CHEMBL35934 IC50 = 53.0 nM 7.28
CHEMBL37141 IC50 = 63.0 nM 7.20
CHEMBL37180 IC50 = 64.0 nM 7.19
CHEMBL36376 IC50 = 180.0 nM 6.75
CHEMBL417327 IC50 = 470.0 nM 6.33
CHEMBL36649 IC50 = 470.0 nM 6.33