Assay Detail
Binding
CHEMBL615389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity in radioreceptor binding assay by using [3H]5-HT radioligand against 5-hydroxytryptamine 1 receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.32 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274866 | — | — | 1 | 7.70 |
| CHEMBL266250 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274866 | — | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL266250 | — | Ki | = | 117.0 | nM | 6.93 |