Assay Detail
Binding
CHEMBL615401
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Binding affinity for 5-hydroxytryptamine 1 receptor of rat prefrontal cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Prefrontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.62 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6616 | — | — | 1 | 6.04 |
| CHEMBL8642 | — | — | 1 | 5.99 |
| CHEMBL18762 | — | — | 1 | 5.88 |
| CHEMBL61002 | — | — | 1 | 5.77 |
| CHEMBL134519 | — | — | 1 | 5.64 |
| CHEMBL16247 | — | — | 1 | 5.58 |
| CHEMBL61355 | — | — | 1 | 5.55 |
| CHEMBL60146 | — | — | 1 | 5.54 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 5.48 |
| CHEMBL16451 | — | — | 1 | 5.46 |
| CHEMBL304023 | — | — | 1 | 5.39 |
| CHEMBL405 | AMPHETAMINE | 4.0 | 1 | 5.12 |
| CHEMBL60248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6616 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL8642 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL18762 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL61002 | — | Ki | = | 1710.0 | nM | 5.77 |
| CHEMBL134519 | — | Ki | = | 2290.0 | nM | 5.64 |
| CHEMBL16247 | — | Ki | = | 2660.0 | nM | 5.58 |
| CHEMBL61355 | — | Ki | = | 2830.0 | nM | 5.55 |
| CHEMBL60146 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 3340.0 | nM | 5.48 |
| CHEMBL16451 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL304023 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL405 | AMPHETAMINE | Ki | = | 7660.0 | nM | 5.12 |
| CHEMBL60248 | — | Ki | > | 25000.0 | nM | - |