Assay Detail
Functional
CHEMBL615478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.74 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276031 | LY-293284 | — | 1 | 9.89 |
| CHEMBL142862 | — | — | 1 | 9.03 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.23 |
| CHEMBL342986 | — | — | 1 | 7.66 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | — | 1 | 6.17 |
| CHEMBL444612 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276031 | LY-293284 | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL142862 | — | EC50 | = | 0.93 | nM | 9.03 |
| CHEMBL56 | 8-OH-DPAT | EC50 | = | 5.82 | nM | 8.23 |
| CHEMBL342986 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL142936 | DIETHYLTRYPTAMINE | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL444612 | — | EC50 | = | 3700.0 | nM | 5.43 |