Compound Detail
CHEMBL276031
LY-293284 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL276031 |
| Name | LY-293284 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CKYZLYQSDNLGPT-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
298.4
MW (Da)
3.96
ALogP
2
HBA
1
HBD
36.1
PSA (Ų)
0.82
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.89
Ki 1 meas. best 10.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 10.06 | 10.06 | 0.1 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | EC50 | 9.89 | 9.89 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 0.088 | nM | 10.06 | Inhibition constant of 50 uM forskolin-stimulated cAMP accumulation against 5-hy... | 11101361 |
| 5-hydroxytryptamine receptor 1A | EC50 | = | 0.13 | nM | 9.89 | EC50 for inhibition of 50 uM forskolin-stimulated cAMP accumulation against 5-hy... | 11101361 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10090793 | 10.1021/jm980692q | Rattus norvegicus | 8 |
| 11101361 | 10.1021/jm000339w | 5-hydroxytryptamine receptor 1A | 3 |
| 10090793 | 10.1021/jm980692q | 5-hydroxytryptamine receptor 2A | 2 |
Data from ChEMBL 36 via Core Engine