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Assay Detail

CHEMBL616506

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition constant of 50 uM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.
Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE.
J Med Chem (2000) 43 : 4701 -4710
PubMed 11101361 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 10.06 10.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL276031 LY-293284 1 10.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL276031 LY-293284 Ki = 0.088 nM 10.06