Assay Detail
Binding
CHEMBL615481
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Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assay.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Ergolines as selective 5-HT1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.54 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288111 | — | — | 1 | 8.52 |
| CHEMBL291097 | — | — | 1 | 8.30 |
| CHEMBL36379 | — | — | 1 | 8.10 |
| CHEMBL39947 | — | — | 1 | 7.82 |
| CHEMBL285723 | — | — | 1 | 7.70 |
| CHEMBL39604 | — | — | 1 | 7.70 |
| CHEMBL285284 | — | — | 1 | 7.40 |
| CHEMBL40047 | — | — | 1 | 7.10 |
| CHEMBL449081 | AGROCLAVINE | — | 1 | 6.85 |
| CHEMBL38058 | — | — | 1 | 6.80 |
| CHEMBL291030 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288111 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL291097 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL36379 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL39947 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL285723 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL39604 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL285284 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL40047 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL449081 | AGROCLAVINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL38058 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL291030 | — | IC50 | = | 240.0 | nM | 6.62 |