Assay Detail
Binding
CHEMBL615486
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Inhibition of [3H]5-HT radioligand binding against 5-hydroxytryptamine 1 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.33 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9669 | — | — | 1 | 7.72 |
| CHEMBL9452 | — | — | 1 | 7.71 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 7.60 |
| CHEMBL275943 | — | — | 1 | 7.58 |
| CHEMBL9666 | — | — | 1 | 7.54 |
| CHEMBL273923 | — | — | 1 | 7.37 |
| CHEMBL9429 | — | — | 1 | 7.24 |
| CHEMBL269784 | — | — | 1 | 7.06 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 6.83 |
| CHEMBL267153 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9669 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL9452 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL275943 | — | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL9666 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL273923 | — | Ki | = | 42.6 | nM | 7.37 |
| CHEMBL9429 | — | Ki | = | 57.9 | nM | 7.24 |
| CHEMBL269784 | — | Ki | = | 86.5 | nM | 7.06 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL267153 | — | Ki | = | 250.0 | nM | 6.60 |