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Assay Detail

CHEMBL615643

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Binding
Inhibition of human rhinovirus 3C protease
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human rhinovirus B
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human rhinovirus A protease (CHEMBL2857)
Type SINGLE PROTEIN
Organism Human rhinovirus sp.

Publication

Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.
Webber SE, Tikhe J, Worland ST, Fuhrman SA, Hendrickson TF, Matthews DA, Love RA, Patick AK, Meador JW, Ferre RA, Brown EL, DeLisle DM, Ford CE, Binford SL.
J Med Chem (1996) 39 : 5072 -5082
PubMed 8978838 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 6.46 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145830 1 8.52
CHEMBL358279 1 8.40
CHEMBL145833 1 8.40
CHEMBL148199 1 8.40
CHEMBL347099 1 8.22
CHEMBL148689 1 8.00
CHEMBL146403 1 7.96
CHEMBL348660 1 7.72
CHEMBL358951 1 7.60
CHEMBL149227 1 7.57
CHEMBL149822 1 7.54
CHEMBL434661 1 7.32
CHEMBL149844 1 5.92
CHEMBL145918 1 5.09
CHEMBL293622 1 5.01
CHEMBL149556 1 5.00
CHEMBL148681 1 4.96
CHEMBL357319 1 4.92
CHEMBL64413 1 4.52
CHEMBL64582 1 4.52
CHEMBL345744 1 4.48
CHEMBL64584 1 4.29
CHEMBL344320 1 4.23
CHEMBL60569 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145830 Ki = 3.0 nM 8.52
CHEMBL358279 Ki = 4.0 nM 8.40
CHEMBL145833 Ki = 4.0 nM 8.40
CHEMBL148199 Ki = 4.0 nM 8.40
CHEMBL347099 Ki = 6.0 nM 8.22
CHEMBL148689 Ki = 10.0 nM 8.00
CHEMBL146403 Ki = 11.0 nM 7.96
CHEMBL348660 Ki = 19.0 nM 7.72
CHEMBL358951 Ki = 25.0 nM 7.60
CHEMBL149227 Ki = 27.0 nM 7.57
CHEMBL149822 Ki = 29.0 nM 7.54
CHEMBL434661 Ki = 48.0 nM 7.32
CHEMBL149844 Ki = 1200.0 nM 5.92
CHEMBL145918 Ki = 8200.0 nM 5.09
CHEMBL293622 Ki = 9700.0 nM 5.01
CHEMBL149556 Ki = 10000.0 nM 5.00
CHEMBL148681 Ki = 11000.0 nM 4.96
CHEMBL357319 Ki = 12000.0 nM 4.92
CHEMBL64413 Ki = 30000.0 nM 4.52
CHEMBL64582 Ki = 30000.0 nM 4.52
CHEMBL345744 Ki = 33000.0 nM 4.48
CHEMBL64584 Ki = 51000.0 nM 4.29
CHEMBL344320 Ki = 59000.0 nM 4.23
CHEMBL60569 Ki > 100000.0 nM -