Assay Detail
Binding
CHEMBL615722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of binding of [3H]-5-HT to 5-hydroxytryptamine 1 receptor in rat cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.46 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92871 | — | — | 1 | 6.46 |
| CHEMBL330471 | — | — | 1 | - |
| CHEMBL92529 | — | — | 1 | - |
| CHEMBL2130744 | — | — | 1 | - |
| CHEMBL90769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92871 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL330471 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL92529 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2130744 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL90769 | — | Ki | > | 1000.0 | nM | - |