Assay Detail
Binding
CHEMBL615781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Pyrrole mannich bases as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.99 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346168 | — | — | 1 | 7.74 |
| CHEMBL347334 | — | — | 1 | 7.56 |
| CHEMBL9666 | — | — | 1 | 7.55 |
| CHEMBL153136 | — | — | 1 | 7.53 |
| CHEMBL434512 | — | — | 1 | 7.48 |
| CHEMBL347056 | — | — | 1 | 7.39 |
| CHEMBL155506 | — | — | 1 | 7.38 |
| CHEMBL347782 | — | — | 1 | 7.30 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 7.24 |
| CHEMBL348002 | — | — | 1 | 7.23 |
| CHEMBL152311 | — | — | 1 | 7.16 |
| CHEMBL357286 | — | — | 1 | 7.12 |
| CHEMBL348241 | — | — | 1 | 7.12 |
| CHEMBL152458 | — | — | 1 | 7.09 |
| CHEMBL152363 | — | — | 1 | 6.92 |
| CHEMBL345506 | — | — | 1 | 6.92 |
| CHEMBL152776 | — | — | 1 | 6.86 |
| CHEMBL152204 | — | — | 1 | 6.85 |
| CHEMBL152336 | — | — | 1 | 6.83 |
| CHEMBL153219 | — | — | 1 | 6.81 |
| CHEMBL153490 | — | — | 1 | 6.73 |
| CHEMBL357532 | — | — | 1 | 6.71 |
| CHEMBL348014 | — | — | 1 | 6.55 |
| CHEMBL153335 | — | — | 1 | 6.52 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 6.08 |
| CHEMBL346881 | — | — | 1 | 6.00 |
| CHEMBL151966 | — | — | 1 | 6.00 |
| CHEMBL153263 | — | — | 1 | - |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | - |
| CHEMBL153161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346168 | — | Ki | = | 18.1 | nM | 7.74 |
| CHEMBL347334 | — | Ki | = | 27.3 | nM | 7.56 |
| CHEMBL9666 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL153136 | — | Ki | = | 29.3 | nM | 7.53 |
| CHEMBL434512 | — | Ki | = | 33.1 | nM | 7.48 |
| CHEMBL347056 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL155506 | — | Ki | = | 41.3 | nM | 7.38 |
| CHEMBL347782 | — | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL348002 | — | Ki | = | 58.9 | nM | 7.23 |
| CHEMBL152311 | — | Ki | = | 68.8 | nM | 7.16 |
| CHEMBL357286 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL348241 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL152458 | — | Ki | = | 82.1 | nM | 7.09 |
| CHEMBL152363 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL345506 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL152776 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL152204 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL152336 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL153219 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL153490 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL357532 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL348014 | — | Ki | = | 283.0 | nM | 6.55 |
| CHEMBL153335 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL267777 | RITANSERIN | Ki | = | 842.0 | nM | 6.08 |
| CHEMBL346881 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL151966 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL153263 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL422 | TRIFLUOPERAZINE | Ki | > | 1000.0 | nM | - |
| CHEMBL153161 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | > | 1000.0 | nM | - |