Assay Detail
Binding
CHEMBL615871
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Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenates
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Ergolines as selective 5-HT1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.32 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37867 | — | — | 1 | 7.77 |
| CHEMBL289517 | — | — | 1 | 7.70 |
| CHEMBL291044 | — | — | 1 | 7.70 |
| CHEMBL288480 | — | — | 1 | 7.58 |
| CHEMBL36980 | — | — | 1 | 7.10 |
| CHEMBL290217 | — | — | 1 | 6.92 |
| CHEMBL13866 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37867 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL289517 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL291044 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL288480 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL36980 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL290217 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL13866 | — | IC50 | = | 360.0 | nM | 6.44 |