Assay Detail
Binding
CHEMBL615873
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Compound was evaluated for the inhibition of [3H]5-HT (concentration of 12 nM) specific binding to rat hippocampus
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.25 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.70 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.00 |
| CHEMBL101480 | — | — | 1 | 6.00 |
| CHEMBL102288 | — | — | 1 | 6.00 |
| CHEMBL432595 | — | — | 1 | 5.52 |
| CHEMBL105646 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL101480 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL102288 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL432595 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL105646 | — | IC50 | = | 5000.0 | nM | 5.30 |