Assay Detail
Binding
CHEMBL615941
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In vitro affinity at 5-hydroxytryptamine 1A receptor of rat hippocampus by [3H]8-OH-DPAT displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.03 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53510 | — | — | 1 | 9.35 |
| CHEMBL116367 | — | — | 1 | 8.49 |
| CHEMBL332178 | — | — | 1 | 8.12 |
| CHEMBL115524 | — | — | 1 | 8.04 |
| CHEMBL119455 | — | — | 1 | 8.02 |
| CHEMBL118771 | — | — | 1 | 7.97 |
| CHEMBL119593 | — | — | 1 | 7.91 |
| CHEMBL117730 | — | — | 1 | 7.90 |
| CHEMBL331005 | — | — | 1 | 7.76 |
| CHEMBL331100 | — | — | 1 | 6.97 |
| CHEMBL324372 | — | — | 1 | 6.82 |
| CHEMBL435779 | — | — | 1 | 6.62 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.53 |
| CHEMBL332490 | — | — | 1 | 6.19 |
| CHEMBL332771 | — | — | 1 | 6.11 |
| CHEMBL119150 | — | — | 1 | 6.00 |
| CHEMBL119577 | — | — | 1 | 5.96 |
| CHEMBL119223 | — | — | 1 | 5.86 |
| CHEMBL334116 | — | — | 1 | 5.79 |
| CHEMBL326159 | — | — | 1 | 5.76 |
| CHEMBL119900 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53510 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL116367 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL332178 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL115524 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL119455 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL118771 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL119593 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL117730 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL331005 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL331100 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL324372 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL435779 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL53 | APOMORPHINE | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL332490 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL332771 | — | Ki | = | 772.0 | nM | 6.11 |
| CHEMBL119150 | — | Ki | = | 995.0 | nM | 6.00 |
| CHEMBL119577 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL119223 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL334116 | — | Ki | = | 1621.0 | nM | 5.79 |
| CHEMBL326159 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL119900 | — | Ki | = | 3300.0 | nM | 5.48 |