Compound Detail
CHEMBL119223
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Basic Information
| ChEMBL ID | CHEMBL119223 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | REHZDUZJCOTDRK-JOCHJYFZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
355.5
MW (Da)
5.33
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.63
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 5.86 | 5.86 | 1380.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 1380.0 | nM | 5.86 | In vitro affinity at 5-hydroxytryptamine 1A receptor of rat hippocampus by [3H]8... | 8784447 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8784447 | 10.1021/jm960188q | 5-hydroxytryptamine receptor 1A | 1 |
| 8784447 | 10.1021/jm960188q | D(1A) dopamine receptor | 1 |
| 8784447 | 10.1021/jm960188q | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine