Assay Detail
Functional
CHEMBL616049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Functional characteristics of a series of N4-substituted 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazines as 5-HT1A receptor ligands. Structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.20 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81728 | — | — | 1 | 9.02 |
| CHEMBL311015 | — | — | 1 | 8.87 |
| CHEMBL82215 | — | — | 1 | 8.54 |
| CHEMBL81118 | — | — | 1 | 8.28 |
| CHEMBL311275 | — | — | 1 | 8.17 |
| CHEMBL81095 | — | — | 1 | 7.90 |
| CHEMBL311976 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81728 | — | EC50 | = | 0.955 | nM | 9.02 |
| CHEMBL311015 | — | EC50 | = | 1.349 | nM | 8.87 |
| CHEMBL82215 | — | EC50 | = | 2.884 | nM | 8.54 |
| CHEMBL81118 | — | EC50 | = | 5.248 | nM | 8.28 |
| CHEMBL311275 | — | EC50 | = | 6.761 | nM | 8.17 |
| CHEMBL81095 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL311976 | — | EC50 | = | 251.19 | nM | 6.60 |