Compound Detail
CHEMBL81118
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Basic Information
| ChEMBL ID | CHEMBL81118 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QHORYEWITOZOQE-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
384.4
MW (Da)
3.38
ALogP
5
HBA
0
HBD
42.0
PSA (Ų)
0.71
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.28
Ki 1 meas. best 8.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 8.87 | 8.87 | 1.3 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | EC50 | 8.28 | 8.205 | 5.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 1.349 | nM | 8.87 | Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat fr... | 9873561 |
| 5-hydroxytryptamine receptor 1A | EC50 | = | 5.248 | nM | 8.28 | Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (ex... | 9873561 |
| 5-hydroxytryptamine receptor 1A | EC50 | = | 7.413 | nM | 8.13 | Compound was tested for its potency against human 5-hydroxytryptamine 1A recepto... | 9873561 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9873561 | 10.1016/s0960-894x(98)00406-5 | 5-hydroxytryptamine receptor 1A | 7 |
Data from ChEMBL 36 via Core Engine