Assay Detail
Functional
CHEMBL616050
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Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Functional characteristics of a series of N4-substituted 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazines as 5-HT1A receptor ligands. Structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.29 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81728 | — | — | 1 | 9.07 |
| CHEMBL82215 | — | — | 1 | 8.55 |
| CHEMBL311015 | — | — | 1 | 8.24 |
| CHEMBL311275 | — | — | 1 | 8.22 |
| CHEMBL81118 | — | — | 1 | 8.13 |
| CHEMBL81095 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81728 | — | EC50 | = | 0.8511 | nM | 9.07 |
| CHEMBL82215 | — | EC50 | = | 2.818 | nM | 8.55 |
| CHEMBL311015 | — | EC50 | = | 5.754 | nM | 8.24 |
| CHEMBL311275 | — | EC50 | = | 6.026 | nM | 8.22 |
| CHEMBL81118 | — | EC50 | = | 7.413 | nM | 8.13 |
| CHEMBL81095 | — | EC50 | = | 31.62 | nM | 7.50 |