Assay Detail
Binding
CHEMBL616152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Functional characteristics of a series of N4-substituted 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazines as 5-HT1A receptor ligands. Structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.98 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311015 | — | — | 1 | 9.64 |
| CHEMBL312339 | — | — | 1 | 9.54 |
| CHEMBL81728 | — | — | 1 | 9.53 |
| CHEMBL311275 | — | — | 1 | 9.49 |
| CHEMBL82215 | — | — | 1 | 9.17 |
| CHEMBL79261 | DU 125530 | 2.0 | 1 | 9.15 |
| CHEMBL81095 | — | — | 1 | 8.98 |
| CHEMBL311976 | — | — | 1 | 8.91 |
| CHEMBL81118 | — | — | 1 | 8.87 |
| CHEMBL1742477 | FLESINOXAN | 2.0 | 1 | 8.77 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 8.26 |
| CHEMBL81733 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311015 | — | Ki | = | 0.2291 | nM | 9.64 |
| CHEMBL312339 | — | Ki | = | 0.2884 | nM | 9.54 |
| CHEMBL81728 | — | Ki | = | 0.2951 | nM | 9.53 |
| CHEMBL311275 | — | Ki | = | 0.3236 | nM | 9.49 |
| CHEMBL82215 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL79261 | DU 125530 | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL81095 | — | Ki | = | 1.047 | nM | 8.98 |
| CHEMBL311976 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL81118 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL1742477 | FLESINOXAN | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL8412 | IPSAPIRONE | Ki | = | 5.495 | nM | 8.26 |
| CHEMBL81733 | — | Ki | = | 31.62 | nM | 7.50 |