Assay Detail
Binding
CHEMBL616057
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Binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampal membranes
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.15 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286725 | — | — | 1 | 10.22 |
| CHEMBL152756 | — | — | 1 | 9.37 |
| CHEMBL345848 | — | — | 1 | 9.22 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.68 |
| CHEMBL152869 | — | — | 1 | 8.35 |
| CHEMBL152159 | — | — | 1 | 8.12 |
| CHEMBL152587 | — | — | 1 | 7.90 |
| CHEMBL357448 | — | — | 1 | 7.70 |
| CHEMBL157322 | — | — | 1 | 7.57 |
| CHEMBL147483 | — | — | 1 | 7.57 |
| CHEMBL156599 | — | — | 1 | 7.54 |
| CHEMBL157388 | — | — | 1 | 7.46 |
| CHEMBL2112905 | — | — | 1 | 7.23 |
| CHEMBL157222 | — | — | 1 | 7.23 |
| CHEMBL347290 | — | — | 1 | 7.10 |
| CHEMBL152304 | — | — | 1 | 7.05 |
| CHEMBL152576 | — | — | 1 | 6.93 |
| CHEMBL152391 | — | — | 1 | 6.91 |
| CHEMBL2112911 | — | — | 1 | 6.90 |
| CHEMBL93403 | — | — | 1 | 6.83 |
| CHEMBL196476 | — | — | 1 | 6.74 |
| CHEMBL433741 | — | — | 1 | 6.57 |
| CHEMBL154050 | — | — | 1 | 6.50 |
| CHEMBL154508 | — | — | 1 | 6.47 |
| CHEMBL315879 | — | — | 1 | 6.40 |
| CHEMBL156845 | — | — | 1 | 6.37 |
| CHEMBL345111 | — | — | 1 | 6.36 |
| CHEMBL345820 | — | — | 1 | 6.24 |
| CHEMBL152010 | — | — | 1 | 6.21 |
| CHEMBL152262 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286725 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL152756 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL345848 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL152869 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL152159 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL152587 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL357448 | — | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL157322 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL147483 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL156599 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL157388 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL2112905 | — | Ki | = | 58.6 | nM | 7.23 |
| CHEMBL157222 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL347290 | — | Ki | = | 78.7 | nM | 7.10 |
| CHEMBL152304 | — | Ki | = | 88.5 | nM | 7.05 |
| CHEMBL152576 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL152391 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL2112911 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL93403 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL196476 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL433741 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL154050 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL154508 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL315879 | — | Ki | = | 397.0 | nM | 6.40 |
| CHEMBL156845 | — | Ki | = | 432.0 | nM | 6.37 |
| CHEMBL345111 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL345820 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL152010 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL152262 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL346692 | — | Ki | = | 1660.0 | nM | 5.78 |
| CHEMBL2112910 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL423040 | — | Ki | = | 7730.0 | nM | 5.11 |
| CHEMBL152679 | — | Ki | > | 850.0 | nM | - |
| CHEMBL305362 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL92713 | — | Ki | > | 850.0 | nM | - |
| CHEMBL61789 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL94265 | — | Ki | > | 850.0 | nM | - |