Assay Detail
Binding
CHEMBL616154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]8-OH-DPAT radioligand
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of a series of 6-substituted-2-pyridinylmethylamine derivatives as novel, high-affinity, selective agonists at 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 71 | 7.80 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46467 | — | — | 1 | 9.46 |
| CHEMBL298260 | — | — | 1 | 9.43 |
| CHEMBL45101 | — | — | 1 | 9.27 |
| CHEMBL147119 | — | — | 1 | 9.20 |
| CHEMBL42294 | — | — | 1 | 9.14 |
| CHEMBL297138 | — | — | 1 | 9.03 |
| CHEMBL348191 | — | — | 1 | 8.92 |
| CHEMBL42618 | — | — | 1 | 8.86 |
| CHEMBL42994 | — | — | 1 | 8.85 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.85 |
| CHEMBL357773 | — | — | 1 | 8.85 |
| CHEMBL147922 | — | — | 1 | 8.81 |
| CHEMBL146669 | — | — | 1 | 8.80 |
| CHEMBL295025 | — | — | 1 | 8.78 |
| CHEMBL44904 | — | — | 1 | 8.76 |
| CHEMBL149648 | — | — | 1 | 8.64 |
| CHEMBL359444 | — | — | 1 | 8.59 |
| CHEMBL280516 | — | — | 1 | 8.57 |
| CHEMBL342754 | — | — | 1 | 8.50 |
| CHEMBL145863 | — | — | 1 | 8.46 |
| CHEMBL146868 | — | — | 1 | 8.46 |
| CHEMBL262431 | — | — | 1 | 8.45 |
| CHEMBL147341 | — | — | 1 | 8.45 |
| CHEMBL147172 | — | — | 1 | 8.39 |
| CHEMBL149302 | — | — | 1 | 8.37 |
| CHEMBL146297 | — | — | 1 | 8.34 |
| CHEMBL414623 | — | — | 1 | 8.22 |
| CHEMBL358258 | — | — | 1 | 8.13 |
| CHEMBL146589 | — | — | 1 | 8.13 |
| CHEMBL146514 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46467 | — | Ki | = | 0.3467 | nM | 9.46 |
| CHEMBL298260 | — | Ki | = | 0.3715 | nM | 9.43 |
| CHEMBL45101 | — | Ki | = | 0.537 | nM | 9.27 |
| CHEMBL147119 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL42294 | — | Ki | = | 0.7244 | nM | 9.14 |
| CHEMBL297138 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL348191 | — | Ki | = | 1.202 | nM | 8.92 |
| CHEMBL42618 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL42994 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL357773 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL147922 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL146669 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL295025 | — | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL44904 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL149648 | — | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL359444 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL280516 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL342754 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL145863 | — | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL146868 | — | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL262431 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL147341 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL147172 | — | Ki | = | 4.074 | nM | 8.39 |
| CHEMBL149302 | — | Ki | = | 4.266 | nM | 8.37 |
| CHEMBL146297 | — | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL414623 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL358258 | — | Ki | = | 7.413 | nM | 8.13 |
| CHEMBL146589 | — | Ki | = | 7.413 | nM | 8.13 |
| CHEMBL146514 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL357655 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL357522 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL147479 | — | Ki | = | 10.72 | nM | 7.97 |
| CHEMBL149069 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL347060 | — | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL358808 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL150184 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL149785 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL146394 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL147869 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL149120 | — | Ki | = | 18.62 | nM | 7.73 |
| CHEMBL46697 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL341628 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL356134 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL149148 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL146563 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL343671 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL148493 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL414443 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL146124 | — | Ki | = | 48.98 | nM | 7.31 |