Compound Detail
CHEMBL147922
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL147922 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RGEBYWBBEQTXJC-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
427.9
MW (Da)
3.70
ALogP
5
HBA
1
HBD
63.0
PSA (Ų)
0.65
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 8.81 | 8.81 | 1.5 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 8.81 | 8.81 | 1.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 1.549 | nM | 8.81 | Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement... | 9836623 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 1.54 | nM | 8.81 | Displacement of [3H]8-OH-DAPT from 5-HT1A receptor in human HEK293 cells measure... | 36202190 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9836623 | 10.1021/jm9804329 | 5-hydroxytryptamine receptor 1A | 1 |
| 36202190 | 10.1016/j.bmcl.2022.129006 | 5-hydroxytryptamine receptor 1A | 1 |
Data from ChEMBL 36 via Core Engine